Build a Better Brain: Reverse Cognitive Decline, Dementia & Alzheimer's with Dr. Dale Bredesen

Better! with Dr. Stephanie

This episode is truly a thought-provoking conversation about Alzheimer's and its unique impact on women with none other than the legendary Dr. Dale Bredesen (who is making his fourth appearance on the show). Dale Bredesen, MD, received his undergraduate degree from Caltech and his medical degree from Duke University. He served as resident and chief resident in neurology at the University of California, San Francisco (UCSF) and as postdoctoral fellow in the laboratory of Nobel Laureate Professor Stanley Prusiner. He was a faculty member at UCLA from 1989 to 1994 and was then recruited by the Burnham Institute to direct the Program on Aging. In 1998, he became the founding president and CEO of the Buck Institute for Research on Aging and adjunct professor at UCSF. In 2013, he returned to the University of California, Los Angeles (UCLA) as director of the Easton Center for Alzheimer’s Disease Research and he is currently a professor.

Dr. Stephanie and Dr. Bredesen delve into the fascinating topic of Alzheimer's as a preventable condition, emphasizing that this is the first generation with the power to make Alzheimer's truly optional. They explore the shift in the common presentation of Alzheimer's, particularly in women, highlighting the rise of subjective or mild cognitive impairment in 52-year-old women.

As always, Dr. Stephanie and Dr. Bredesen provide actionable solutions for preventing and managing Alzheimer's, covering diet, exercise, sleep, supplementation, and testing. They introduce innovative blood tests, discuss the importance of a "cognoscopy," and even touch on dental health's role in brain health.

Resources Mentioned:

Reversal of Cognitive Decline: 100 Patients - https://www.omicsonline.org/open-access/reversal-of-cognitive-decline-100-patients-2161-0460-1000450-105387.html

Transcriptional Effects of ApoE4: Relevance to Alzheimer’s Disease - Transcriptional Effects of ApoE4: Relevance to Alzheimer’s Disease

ReCODE: A Personalized, Targeted, Multi-Factorial Therapeutic Program for Reversal of Cognitive Decline. - https://pubmed.ncbi.nlm.nih.gov/34680464/

Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? - https://pubmed.ncbi.nlm.nih.gov/36774227/

Reversal of cognitive decline: a novel therapeutic program - https://pubmed.ncbi.nlm.nih.gov/25324467/

Reversing the effects of Alzheimer's Disease: Dr. Ron Geyer on NeuroEPO - https://medicine.usask.ca/news/2023/reversing-the-effects-of-alzheimers-disease-dr.-ron-geyer-on-neuroepo.php

Dr. Bredesen’s TedX talk - https://youtu.be/TzJSCttlQmc?si=sEC_psvctDR0XRkz

Dr. Bredesen’s books - https://www.apollohealthco.com/books/

KetoFLEX 12/3™ - https://ketoflex.apollohealthco.com

Evanthea Dementia Reversal Trial - https://www.dementiareversaltrial.com

Instagram - https://www.instagram.com/drdalebredesen/

Episode Overview:

0:00:00 Introduction

0:05:42 Welcome to Dr. Dale Bredesen

0:11:59 Factors driving the shift in Alzheimer's disease onset age

0:15:41 COVID-19 and Alzheimer's disease risk

0:21:28 The importance of addressing chronic conditions

0:24:01 The role of metabolic health in cognitive decline

0:25:40 The role of diet in Alzheimer's disease

0:26:54 The postmenopausal women and cognitive decline

0:35:05 Alzheimer's disease and genetic factors

0:36:53 How we could confuse perimenopause with Alzheimer's

0:44:39 ApoE4 and the evolution of hominids

0:47:42 ApoE4 and its pro-inflammatory effect

0:51:23 The limitations of targeting neurofibrillary tangles and plaques

0:54:23 Evaluating the efficacy of drugs for Alzheimer's treatment

1:04:39 Exploring the use of supplementation in the trial

1:05:45 The seven fundamentals for maintain good brain health

1:13:57 Importance of sleep hygiene and nasal breathing

1:18:38 Tailoring sleep habits to circadian rhythms and environmental factors

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