Estradiol Complicates Everything: Toxicology across the Gender Spectrum

Adverse Reactions

When it comes to hormones, everyone has them all, but their levels are where things get interesting. How chemicals affect estrogen signaling in the brain is the research focus of Troy Roepke, Rutgers, who talks to co-hosts Anne Chappelle and David Faulkner about how gender is not easily defined biologically, what it is like to be a “fabulously queer” professor, and how science can better serve the LGBTQ+ and other marginalized communities.
About the Guest
Troy Roepke, PhD, is an Associate Professor in the Rutgers School of Environmental and Biological Sciences Department of Animal Sciences, where their research goal is for a greater understanding of the interaction between novel steroid (estrogen) signaling pathways, neuroendocrine functions, maternal and adult diets, and endocrine-disrupting chemicals on homeostatic functions controlled by the hypothalamus, as well as the long-term consequences of maternal exposures to low doses of endocrine-disrupting chemicals in model species and how these maternal exposures may affect normal adult offspring physiological functions.
In addition to their teaching and lab duties, Dr. Roepke serves as Associate Dean of Diversity, Equity, and Inclusion for the Rutgers School of Environmental and Biological Sciences. Dr. Roepke believes one of the most important aspects of being an openly queer professor is to create a lab environment that is supportive of all historically excluded students and trainees, especially LGBTQ+ students. They believe that great science happens when one creates a supportive, diverse, and inclusive environment that prioritizes teamwork, positivity, and respect wherein each team member feels welcomed and encouraged to bring their true authentic selves to the lab.
Dr. Roepke received a doctorate in physiology with a designated emphasis in reproductive biology from the University of California Davis in 2005. Their postdoctoral training was at Oregon Health & Science University, studying the neuroendocrinology of estrogens from 2005 to 2011 where they were the recipient of a K99/R00 Pathways to Independence Award from the National Institute of Diabetes and Digestive and Kidney Diseases to study how endocrine disruptors influence metabolism.

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1. Introduction to the Episode (00:00:00)

2. How Endocrine-Disrupting Chemicals Affect Estrogen Signaling in the Brain (00:01:20)

3. Let’s Talk about Sex (Gender) Misconceptions (00:05:22)

4. Pivoting from Marine Biology to Toxicology (00:07:52)

5. The Fabulously Queer Professor on Campus (00:11:12)

6. Estradiol Complicates Everything (00:12:55)

7. Overlap in the Data between Genders (00:16:39)

8. The Need to Clearly Define Animal Models’ Biological Characteristics (00:19:23)

9. The Danger of Etiology Regarding Sex and Gender (00:21:54)

10. What Was a Significant Adverse Reaction in Your Life? (00:25:18)

11. Episode Credits (00:26:47)