Trial of the Week: REDUCE

Pharmacy to Dose: The Critical Care Podcast

Trial of the Week: REDUCE

Special Guest: Matt Duprey, PharmD, PhD, BCCCP

Matt Duprey joins to discuss the March Trial of the Week, published in 2018 in JAMA: “The Effect of Haloperidol on Survival Among Critically Ill Adults with a High Risk of Delirium: the REDUCE Randomized Clinical Trial.”

We review the history of antipsychotic pharmacotherapy treatment and prophylaxis in delirium, reviewing guideline recommendations from that time. Then we dive into the Trial of the Week: REDUCE trial and discuss its findings as well as study design. Would results be the same with another medication? Why is delirium research so challenging? Prevalent v. incident delirium? What’s the best outcome to measure? What questions still need answered? These questions and so much more are answered in today's episode.

Reference list: https://pharmacytodose.files.wordpress.com/2024/03/reduce-references.pdf

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