Migraines: Are They More Than a Headache?

MedEvidence Articles

In this episode, we explore the intricate world of migraines, a condition affecting one in eight people globally. Discover the five phases of a migraine—prodrome, aura, headache, postdrome, and interictal—and how each contributes to the overall experience. We delve into the role of the hypothalamus, the brain's stability center, in triggering migraines and the various symptoms it causes. Learn about potential triggers, the pain pathways involved, and effective relief methods. Tune in to understand migraines better and find ways to manage this disabling condition.
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References:
Burstein, R., Noseda, R., & Borsook, D. (2015). Migraine: multiple processes, complex pathophysiology. Journal of Neuroscience, 35(17), 6619-6629. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412887/

Kelman, L. (2004). The premonitory symptoms (prodrome): a tertiary care study of 893 migraineurs. Headache: The Journal of Head and Face Pain, 44(9), 865-872. https://doi.org/10.1111/j.1526-4610.2004.04168.x

Koren, M. J., Toenjes, S. (May 13, 2024). Two docs talk: Migraines. MedEvidence Podcast. (Podcast). https://medevidence.com/two-docs-talk-migraines

International Headache Society. (2019). 1.3 Chronic migraine https://ichd-3.org/1-migraine/1-3-chronic-migraine/ Accessed 15 Jan 2024.

Maniyar, F. H., Sprenger, T., Monteith, T., Schankin, C., & Goadsby, P. J. (2014). Brain activations in the premonitory phase of nitroglycerin-triggered migraine attacks. Brain, 137(1), 232-241. https://academic.oup.com/brain/article/137/1/232/363839

May, A., & Burstein, R. (2019). Hypothalamic regulation of headache and migraine. Cephalalgia, 39(13), 1710-1719. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164212/

Saper, C. B., & Lowell, B. B. (2014). The hypothalamus. Current Biology, 24(23), R1111-R1116. https://www.sciencedirect.com/science/article/pii/S0960982214012998