Blood Vessel Organoids for Cruelty-Free Drug and Cosmetics Testing: Dr. Paul Bradfield, MesenFlow

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A drug that works for a mouse might not work for a human. How about testing drugs for inflammatory diseases – and cosmetics – on human organoids?
You’ll hear

• what are human vascular organoids
• and how to grow human cells

also about

• the mechanisms of inflammation and the ability to see where drugs can block it
• arthritis and other chronic inflammatory diseases
• personalized medicine
• cosmetics not tested on animals
• a terrifying process of founding a startup
• a death, a theft, a fire, and an obsessive mindset that kept the lab standing

Dr. Paul Bradfield is a scientist turned an efficient CEO. An expert in drug development and assay development, he has specialized in inflammatory diseases. After laboratory head at Merck Serono, he took an entrepreneurship path and founded MessenFlow.
MessenFlow is a Swiss scale-up that has developed a platform for animal-free accelerated drug and cosmetics development. Their human tissue engineering system mimics human inflammation and allows us to, literally, see the movement of leukocytes in blood vessels.
Here are more details about what the lab can do:
http://mesenflow.com
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The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

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1. Dr. Paul Bradfield and MesenFlow (00:00:00)

2. What Are Organoids (00:01:12)

3. Limits of Today's Pre-clinical Drug and Cosmetic Testing on Mouse Models (00:04:59)

4. How to Build a System That Works Like a Human Inflammatory Pathology (00:10:45)

5. Organoids for Chronic Inflammatory Diseases (00:14:41)

6. Vascular Organoids and Recording White Blood Vessels Move (00:16:32)

7. Testing a Drug on a Human Organoid Blood System (00:25:10)

8. Organoids for Personalized Medicine (00:28:47)

9. What's Leukocyte Recruitment and Transmigration (00:30:48)

10. What's the Higher Throughput (00:35:57)

11. Pushed from Science to Disruptive Biotech Startup (00:38:11)

12. Organoids for Cosmetics Testing (00:46:46)

13. Terrifying Bootstrapped Startup Beginnings and Challenges (00:49:52)

14. Scaling Up in the Field of Organoid Drug and Cosmetics Testing (00:56:27)

15. Thank You, Follow MesenFlow (00:59:24)

16. Follow X-Health.show, Disclaimer (00:59:53)