Vascular Pathogenesis in Long COVID

Heliox: Where Evidence Meets Empathy

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Kruger A, Joffe DJ, Lloyd-Jones G, et al. Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook. Semin Thromb Hemost. 2024; https://doi.org/10.1055/s-0044-1790603
https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0044-1790603.pdf
@DavidJoffe64 @PutrinoLab @SalamonSMD @resiapretorius @ArneauxK

This article examines the role of vascular dysfunction in both acute and long COVID, proposing that persistent thrombotic endothelialitis is a key driver of long-term symptoms. The authors review the scientific evidence for widespread endothelial dysfunction leading to chronic symptomatology, explore potential therapeutic interventions, and highlight the need for early intervention to prevent long-term vascular and cellular dysfunction. The article also explores the potential role of viral persistence and oral dysbiosis in ongoing endothelial inflammation in Long COVID.
NOT YET RECRUITING
Lumbrokinase for Long Covid Clinical Trial
ClinicalTrials.gov ID NCT06511050
Sponsor Icahn School of Medicine at Mount SinaiInformation provided by David Putrino, Icahn School of Medicine at Mount Sinai (Responsible Party)Last Update Posted 2024-08-09
https://clinicaltrials.gov/study/NCT06511050?cond=Long%20COVID%20&intr=Lumbrokinase&rank=1

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