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Join DNA Dan as he dives deep into the world of genetics, genomics, DNA, and the future of precision genomic medicine. Dan discusses topics ranging from health and ancestry genetic testing, forensic genetics, genetics and mental health, common myths about genetics, and more. DNA Dan, SCU Professor of Genomics, Dan Handley, M.S., Ph.D., shares his knowledge from his over 30 years of experience in the world of advanced genomics research and biotechnology. For more information about Southern Ca ...
 
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If you think back to your early years of biology class, you may remember learning about tiny cellular energy factories, called mitochondira. Mitochondria are microscopic powerhouses hiding within most cells and they play a huge role in our health. Damaged mitochondria can lead to a host of health issues. But healthy mitochondria can result in optim…
 
This week I spoke to Alka Gupta. Alka has just finished up her PhD and begun her postdoctoral position at UCSC in the Sharma Lab where she is now working on epigenetic inheritance. Today we spoke about her PhD research in which she was looking at the role of microRNAs in male infertility. We learnt about Sertoli cells, spermatogenesis and shrinking…
 
Today I speak to Dr Paul Okunieff , founder and consultant of Diacarta. DiaCarta is a leading translational genomics and personalized diagnostics company based in California. DiaCarta provides highly sensitive and advanced technologies aiming to change the landscape of precision medicine and molecular diagnostics by impacting healthcare treatment p…
 
Over the 1960s through 1980s, more was learned about the structure of chromosomes and the functions of some genes. However, we did not have a comprehensive map of the entire human genome. Learn how molecular biology techniques become more sophisticated, and scientists could start determining the nucleotide sequence of small portions of chromosomes.…
 
In each nucleus of a human cell, the total length of DNA contained in it is about 6 feet long. Now, the size of a nucleus in a human cell is only 6 microns in width. A micron, otherwise called a micrometer, is 1 one-millionth of a meter. To put this in perspective, the average human hair is about 100 micrometers in diameter, and a grain of salt is …
 
On todays episode, I speak to Sudarshan Pinglay, a PhD student from NYU medical center. Sudarshan is involved in the dark matter project- we talk about the dark matter of the genome, where introns, repetitive and regulatory elements reside. Sudarshan works specifically on the HOXA locus. The Hox family of genes pattern the head to tail axis in the …
 
In todays episode, I speak to Dr Hamish King, a Sir Henry Wellcome Fellow affiliated with the Blizard Institute at Queen Mary University of London. Hamish is interested in how errors in gene regulation lead to changes in the behaviour and function of B cells, an important cell type in our immune system that makes antibodies to fight and remember in…
 
Welcome to Episode 29 of The Genomics Lab! On today's episode we talk to Alexandria Andrayas who is a PhD candidate in the Soc-B Centre for doctoral training which is a new and unique programme in biosocial research. The programme is funded by the Economic and Social Research Council and the Biotechnology & Biological Sciences Research Council. It …
 
Today we understand much more detail about the structure of DNA. It turns out that Watson, Crick, Wilkins, Franklin, and the many others involved gave essentially the correct answer about the DNA molecule and how it is structured. ------------------------------------------ Join DNA Dan each month as he dives deep into the world of genetics, genomic…
 
Welcome to Episode 28 of The Genomics Lab! On today's episode we talk to Dr.Patrick CN Martin who is a postdoctoral researcher at the University of Copenhagen. He completed his PhD in Dr Radu Zabets lab in 2020 where he investigated the binding mechanisms of transcription factors to DNA. His research involved development of an R package, ChIPAnalys…
 
Rosalind Franklin played a pivotal role in the discovery of the structure of DNA. Among scholarly circles, Franklin remains an enigmatic figure and the subject of much controversy. What is not under debate is that she made enormous contributions to science, and she was taken from us much too soon. ------------------------------------------ Join DNA…
 
This week we are honoured to host Professor Wendy Bickmore, the Director of the MRC Human Genetics unit at the University of Edinburgh. Wendys research laboratory focuses on trying to better understand the 3D organisation of the genome, and how this controls how the genome functions during normal development. They are further interested in how this…
 
Now the race was on to figure out the structure of DNA. It’s a rather complex story involving many different scientists, primarily in the U.S. and England. ------------------------------------------ Join DNA Dan each month as he dives deep into the world of genetics, genomics, DNA, and the future of precision genomic medicine. Dan discusses health …
 
In this episode, part 2 of the discovery of DNA, we come to understand how DNA was first isolated and demonstrated to be the molecule responsible for heritable traits. In the early to mid-19th century, biologists assumed that heritable traits were transmitted by proteins in cells. ------------------------------------------ Join DNA Dan each month a…
 
Since prehistoric times, people have noticed how children tend to resemble their parents and grandparents. People also recognized that some human diseases tended to run in families as well. Learn why this happens and how it was discovered. What is the substance in cells that carries the heritable trait information? Further, what is the structure of…
 
Welcome back! Today we are talking to Kathleen Ivey, a PhD student from the University of Texas at Arlington in the Castoe Lab. Kat talks to us all about her journey to her PhD, with a background in vet tech & herpetology. Kat now focuses on population genomics, with a particular interest in Rattlesnakes. She tells us all about being out in the fie…
 
Dr. Handley serves as Director of the Master of Science in Human Genetics and Genomics degree program at the Southern California University of Health Sciences in Whittier, CA. He is excited to bring you this podcast on genetics, genomics, and the future of genomic medicine! Join DNA Dan each month as he dives deep into the world of genetics, genomi…
 
Welcome back for another episode! This week we chat to Dr Peter Sarkies from Imperial College London / MRC LMS! Peter is a senior lecturer running his own laboratory which aims to make connections between epigenetic gene regulation and evolution. Peter talks to us all about his research involving investigation of a wide range of epigenetic pathways…
 
On todays episode, we talk to Dr Sarah Marzi from Imperial College London all about her work into the epigenetic regulation in neurodegenerative diseases like Alzheimers and Parkinsons. Sarah tells us about her journey into this field and describes what exactly neurodegenerative diseases are?! She also talks to us about her contributions to the fie…
 
This week we took a slight detour away from our normal topic of conversation (Genomics) and immersed ourselves into the world of DNA nanotechnology with Dr Andrew J Lee, the centre manager of the Bragg Centre for materials research. Andy is a weaver of DNA and nanoscale filmaker in the Bioelectronics group. He develops nanostructures that are self …
 
Our second guest from the Garvan Institute of Medical Research in Sydney, is DrOzren Bogdanovic. We are so privileged to talk today to Ozren about his work in developmental epigenetics which covers how DNA methylation participates in diverse developmental processes, and how deposition and removal of the methylation mark impacts upon embryonic and g…
 
On todays episode we speak to Dr Adam Wende and Dr Mark Pepin! We discuss their recent publication which has been all over twitter recently! During the research, they identified an association between socioeconomic factors, the methylome, & heart failure. We discuss all of the motivations, methodological techniques and interesting findings from the…
 
In today's episode we speak to Dr Birgitte Regenberg and Dr Sam Keating from the Regenberg Lab, University of Copenhagen, about extrachromosomal circular DNA and it's significance in human disease. Circular DNA originates from chromosomes but differs from linear chromosomes as they mostly don’t have centromeres - so if a gene is trapped on a circle…
 
We've reached episode 20!!! In celebration of our twentieth episode, we are speaking today to Dr Cátia Moutinho about single cell sequencing and spatial omics - two up and coming techniques that everyone seems to be talking about at the moment. Cátia is Group Leader of the Single Cell Technology Development in the Garvan Institute in Sydney, Austra…
 
This week we speak to Anna Postsch. Anna is a group leader at the biotechnology center at the University Dresden! Her group employs computational techniques and machine learning approaches to assess and model DNA damage and repair processes, mutagenesis and genome editing to develop clinical applications. We also had some interesting conversations …
 
On this weeks episode we are discussing Cancer and developmental biology in genomics with Dr Myron Evans! Myron is currently a post doctoral research fellow at St Judes Childrens research hospital in Memphis, Tennesse! Myron discusses with us his journey into cancer biology and shares a unique perspective of life working at a research hospital. He …
 
We're back after the Easter Break with an extremely interesting episode with Dr Peter Ellis from the School of Biosciences at the University of Kent! Dr.Ellis is a Lecturer in Molecular Genetics and Reproduction at the University of Kent. His research thus far has involved the identification of novel genes on the mouse Y chromosome that affect sper…
 
Join us today as we speak to Dr Maxim Greenberg, located at the Institut Jacques Monod in the heart of Paris. IJM is one of the premier institutes for fundamental research in the life sciences in France. Maxim's lab aims to better understand the epigenetic consequences of DNA methylation during a specific window of development which occurs in the f…
 
Join us today as we speak to Dr David Tumbarello, from the University of Southampton, as he talks to us about his dynamic and varied academic career that has taken him from New York, to Southampton, stopping off at a number of places in between!! David's lab currently focuses on understanding the cellular mechanisms and molecular machinery required…
 
In today's episode, we speak to Dr Jordi Paps-Montserrat, lecturer in the School of Biological Sciences at the University of Bristol. Jordi did his PhD at the University of Barcelona, before completing his post-doc at the University of Oxford. We talk with Jordi today about his work on evolutionary genomics, and how we can elucidate biological adap…
 
Join us today as we speak to an inspirational Woman in STEM, Sethlina Naa Dodua Aryee, raised in Ghana, who moved to the University of Cambridge to complete her PhD in sustainable food production through the use of genomic and bioinformatic tools - a global issue that she has been passionate about for her whole life. Sethlina speaks to us today abo…
 
In order to celebrate International Women's Day 2021, we have picked two inspirational role models at our University and invited them to speak to us about their experiences of being a woman in science. We learn about their varied and exciting careers, and then we discuss all of our personal experiences of being a woman in science - from how we were…
 
In today's episode, we are excited to be talking to Dr Christopher Clarkson, currently based at UCL, where he has just started a post-doctoral research position. In 2020, Dr. Clarkson completed his PhD at the University of Essex where he investigated changes of nucleosome positioning and 3D chromatin organization! In today's episode, we discuss how…
 
In today's episode, we are privileged to be speaking to Professor Darren Griffin, who is currently based at the University of Kent, where he is the director of the Centre for Interdisciplinary Studies of Reproduction, and Professor of Genetics. Darren is President of the International Chromosome and Genome Society, and is a world leader in the fiel…
 
Don't miss today's episode, as we are joined by Nicky Hales, who runs a Genomics Core Facility in Texas! This episode is a little different to usual, as we are focusing more on a genomics based career path, and excitingly, it's a career path we did not know much about - so it was a real learning curve to talk to Nicky. Nicky explains to us how she …
 
Something a little different - our first BONUS episode. Today we talk to Brad and Joe about our experience of using social media as a networking an science communications tool. Brad and Joe briefly introduce their research (for once, not genomics......) and we then discuss the pros and cons of a number of social media platforms, as well as the powe…
 
Welcome to Episode 6 of The Genomics Lab! On today's episode we talk to Alexandria Andrayas who is a PhD candidate in the Soc-B Centre for doctoral training which is a new and unique programme in biosocial research. The programme is funded by the Economic and Social Research Council and the Biotechnology & Biological Sciences Research Council. It c…
 
Welcome to Episode 5 of The Genomics Lab! On today's episode we talk to Jareth Wolfe who is a final year PhD student at the University of Essex. We talk to Jareth today about his work on using explainable artificial intelligence models in order to identify enhancers in DNA. Jareth explores the link between histone modifications and enhancers, expla…
 
Welcome to Episode 1 of The Genomics Lab! On today's episode we talk to Jess Chadwick who is a third year PhD researcher at Imperial College London. She is doing her PhD in molecular neuroscience, investigating the molecular mechanisms of axonal regeneration after spinal cord injury. Jess talks to us about how axonal injury in the spinal cord usual…
 
Welcome to Episode 3 of The Genomics Lab! On today's episode we talk to Laura Whelan, who is a PhD researcher at the School of Genetics & Microbiology at the Trinity College Dublin. Laura is part of the Target 5000 programme; the first large-scale study to apply next generation sequencing to the Irish inherited retinal diseases (IRD) patient popula…
 
Subscribe for free now and listen to the first episode of The Genomics Lab before anyone else! Welcome to the Genomics Lab! We are Olivia Grant and Eleanor Watson, two PhD candidates in the Genomics research group at the University of Essex. In this podcast, we chat to researchers in the field and speak to them about their current research, saving …
 
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